During an infection, viruses spread from infected to uninfected cells and can be spread cell-to-cell. Here, murine leukemia virus undergoes cell-to-cell transmission via filopodial bridges to physically link the two cells.
Image: Cos-1 cells generating murine leukemia virus (MLV) expressing Gag-YFP (red) were co-cultured with uninfected XC target cells expressing the MLV receptor mCAT-1-CFP (green) and imaged using time-lapse fluorescence microscopy. Images were taken approximately every 2 minutes and compiled in a time-lapse movie. Learn more in Sherer et al.(2007) and Jin et al. (2009).